PF 05180999
CAS No. 1394033-54-5
PF 05180999 ( PF-05180999;PF05180999;PF 5180999 )
产品货号. M11643 CAS No. 1394033-54-5
PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
规格 | 价格/人民币 | 库存 | 数量 |
25MG | ¥2558 | 有现货 |
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50MG | ¥4322 | 有现货 |
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100MG | 获取报价 | 有现货 |
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200MG | 获取报价 | 有现货 |
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500MG | 获取报价 | 有现货 |
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1G | 获取报价 | 有现货 |
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生物学信息
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产品名称PF 05180999
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注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
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产品简述PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM.
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产品描述PF-05180999 (PF 5180999) is a potent, selective, brain-penetrating and orally bioavailable phosphodiesterase 2A (PDE2A) inhibitor with IC50 of 1 nM; displays >1,000-fold selectivity over PDE10; shows potential for treatment of schizophrenia.Schizophrenia Phase 1 Discontinued
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同义词PF-05180999;PF05180999;PF 5180999
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通路Angiogenesis
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靶点PDE
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受体PDE
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研究领域Neurological Disease
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适应症Schizophrenia
化学信息
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CAS Number1394033-54-5
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分子量414.40
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分子式C19H17F3N8
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纯度>98% (HPLC)
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溶解度DMSO : 50 mg/mL 120.66 mM
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SMILESFC(C1=CN=C(C2=C(C3=C4C(N5CCC5)=NC=NN4C(C)=N3)C=NN2C)C=C1)(F)F
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化学全称4-(1-Azetidinyl)-7-methyl-5-[1-methyl-5-[5-(trifluoromethyl)-2-pyridinyl]-1H-pyrazol-4-yl]-imidazo[5,1-f][1,2,4]triazine
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1. Mikami S, et al. J Med Chem. 2017 Sep 28;60(18):7677-7702.
2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.
2. Helal CJ, et al. J Med Chem. 2018 Jan 2. doi: 10.1021/acs.jmedchem.7b01466.
产品手册
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